What exactly is RAD-140
RAD-140 is also commonly known as Testolone. This research chemical was engineered to help in the treatment of various conditions such as muscle wasting disorders and cancer. However, Testolone has become very popular for entirely different reasons. Due to the compounds high affinity to androgen receptors, RAD-140 found its new home in the bodybuilding industry. As a selective androgen receptor modulator, RAD-140 binds to the androgen receptors located in the muscle tissue to create a high anabolic environment suitable for muscle growth. It’s therefore, not shocking to see that it has become a darling in the fitness platform.
This doesn’t change the fact that RAD-140 is still a research chemical though. It means that the substance is not approved for human consumption, but that hasn’t stopped bodybuilders from using the compound anyway. If you are planning to get on this train of RAD-140 users, it’s only fair that you learn everything there is to know about the compound. This review is tailored to help with just that.
History of RAD-140
Testolone belongs in the group of chemicals known as selective androgen receptor modulators (SARMs). The development of SARMs started as early as the 1940s. These chemicals were being developed to treat muscle wasting disorders, osteoporosis, obesity, cancer, and bone health issues. In the first phases of clinical trials involving these compounds, the reports showed impressive performance-enhancing properties, and this is how the chemicals grabbed the attention of the fitness experts.
Testolone is the newest SARM in the market. This chemical was discovered in 2010, but it has already made quite a name for itself. Just like the rest of the SARMs, Testolone has proven to be more than capable of delivering the desperately-needed bodybuilding results without the undesirable effects that were common among steroid users. Unfortunately, the short period of existence of this compound means that there is very little that’s known about it. The first human trials actually began in 2017, and the results have been nothing short of impressive thus far. On the flip side, the lack of sufficient data means that we do not know what the long term effects of this chemical can be. So far, we are forced to rely on the limited information on human trials, lab studies, and anecdotal data. If these three sources are anything to go by, then RAD-140 is definitely an incredible substance worth giving a shot.
RAD-140 is currently under the development of a public traded pharmaceutical giant known as Radius Health Inc. According to the company, RAD-140 is showing promising signs of becoming an effective treatment for muscle wastage and breast cancer. Hopefully, we will see more scientific evidence on the full spectrum of both the health and bodybuilding effects of the substance soon.
Benefits of RAD-140
Before we give you an overview of the benefits of RAD-140, let’s first answer a simple question; how does RAD-140 work to deliver the numerous benefits it is associated with. If you are well-familiarized with SARMs, then you probably know how Testolone works. As a selective androgen receptor, Testolone binds onto the androgen receptors to promote muscle growth and many other effects. Here is the thing though, androgen receptors are found all over the body which means that if a substance like RAD-140 goes on stimulating the receptors left, right and center then health complications are bound to happen. The good news is that Testolone just like all other SARMs has high specificity and that’s why they are referred to as selective androgen receptor modulators. This compound will strictly deal with the androgen receptors located in your muscle and bone tissues. It’s also for this reason that Testolone gets the upper hand over anabolic-androgen steroids. The substance will deliver the bodybuilding effects linked to steroids without unpleasant side effects.
It’s also fair to point out that the selective nature of Testolone does not make them as powerful as steroids. But isn’t it worth it to have a reasonably potent substance that will give you the incredible results you need, in the long run, without putting your life at risk?
Anyway, RAD-140 can deliver the following benefits:
- Increases muscle mass
The whole purpose behind the development of RAD-140 was to deal with muscle wasting disorders resulting from chronic conditions such as cancer, multiple sclerosis, and AIDs. The substance was hence tailored to prevent the condition, but trials have shown that it can go a step further to enhance muscle growth.
How does it achieve that? Well, when the Testolone binds to the androgen receptors in muscle tissues, it initiates the process that promotes the growth of muscle tissues. The substance will also allow your body to grow muscle mass a lot faster than you would under normal circumstances.
Testolone is also known to cause weight gain. Don’t worry though, because trials show that the increase in weight is primarily due to the growth of muscle and bone tissues both of which are fundamental for successful bodybuilding.
- Prevents neurodegenerative disorders
According to various trials involving rats, RAD-140 protected the brain nerves from amyloid beta proteins. These are the same culprits linked to conditions such as Alzheimer’s disease.
Based on these studies, it is believed that Testolone can help in fighting Alzheimer’s and other neurodegenerative disorders by preventing the accumulation of amyloid beta proteins. The substance will have an almost similar impact as testosterone, but the best part is that using RAD-140 for this purpose does not increase the risk of prostate cancer as is the case with testosterone.
We still need clinical trials to shed some light on how RAD-140 can be used for this purpose.
- Treatment of breast cancer
This is one of the goals behind the creation of this chemical. Radius Health Inc is currently investigating the impact of RAD-140 in treating Androgen Receptor and Estrogen Receptor Positive breast cancer (AR/ER+ breast cancer).
Trials done on cells from patients with this type of cancer have shown promising results. Scientists reported that RAD-140 suppressed the growth of cancer cells by preventing the secretion of a protein known as ESR1. This blocked the effects of estrogen on the tissues thus preventing further growth of the cancerous cells.
- Stimulates weight loss
RAD-140 users reported weight loss after using the SARM for some time. It is believed that this substance achieves this by increasing the muscle and bone cells. Consequently, metabolic rate goes up which allows your body to burn down more fat thus resulting in fat loss.
RAD-140 may also promote weight loss by reducing the amount of circulating fat molecules known as low-density lipoprotein (LDL).
All the evidence of weight loss is based in anecdotal data though. So far, no trial has shown a direct correlation between Testolone and fat loss.
- Boosts stamina
Testolone users around the world have reported working out for more extended periods since they started taking this SARM. It increases lean muscle mass, and it also cuts down on fat which makes working out a lot easier.
The ability to spend more time in the gym sets the perfect tone for super-productive workout sessions that should see you achieve your bodybuilding goals much faster.
Side Effects of Testolone
Everyone knows that all SARMs are a lot safer to use than anabolic androgenic steroids. Testolone is no exception. What most vendors and SARM’s manufacturer won’t tell you is that even these compounds come with some risk of medical complications. The effects may not be as severe as the ones witnessed by AAS users, but they are adverse reactions nonetheless.
The first thing that we must discuss is the lack of enough clinical data on Testolone. This substance is barely a 10-years old, and human trials began less than 2 years ago. It’s, therefore, reasonable to think that there might be some serious long term side effects about this substance that we are not aware of yet. The good news is that so far, no bodybuilders have reported severe medical complications due to using RAD140.
Some of the commonly reported side effects of Testolone is hair loss, shedding, headaches, and insomnia. Most of the users who reported issues on headache and insomnia managed to eliminate the problem by readjusting the doses to tolerable levels. As of the other two side effects, there is very little that one can do to avoid them.
Research also claims that RAD-140 may have some testosterone related side effects such as:
- Changes in sex drive
- Mood swings
- Anxiety and depression
- Breast tenderness in men
- Gynecomastia is also a possibility
RAD-140 is relatively safe for use by women. Unfortunately, high levels of Testolone may lead to virilization, i.e. expression of masculine traits on women. It’s possible for women to experience an increase in abdominal hair growth, enlargement of the clitoris and deepening of the voice. These effects can be avoided by taking low doses of RAD-140 in short cycles.
Testolone is usually cycled for 8 to 12 weeks. New users prefer starting with shorter cycles of 8 weeks while sticking with low doses while the experienced bodybuilders can comfortably tolerate RAD-140 for up to 12 weeks.
It is crucial that all users take a break when using Testolone. This should give your body some time to readjust back to its normal chemical processes. It also helps to restore normal production of testosterone which is very important if you want to keep your gains.
It’s advisable that you prepare and have your post cycle therapy ready before you even start taking Testolone or any other SARM for that matter. It is common to find arguments of people claiming that using Testolone properly means that PCT is not required. That will be a terrible mistake. It’s vital to run PCT even if you were already using some medications to maintain proper secretion of testosterone during your cycle. It’s better to be safe than sorry, right?
How long should you take a break from PCT? It’s advisable to take a break that is just as long your cycle was. For instance, if you were using Testolone for 8 weeks, your break should also be 8 weeks long. Some people are known to take slightly shorter breaks, e.g. 12 weeks on-cycle followed by an 8-weeks break. This may also work if you were taking low doses or if your body demonstrated excellent tolerability to the substance. In other cases, some users are forced to take an even more extended break, e.g. an 8-week cycle followed by a 12-weeks break. This is common in people whose body took a heavy toll from the high levels of RAD-140 consumed. The long break helps to make sure that your body recovers appropriately before you start retaking the substance.
So, the question is; how do you know how much break your body needs? A break that is as long as the duration of your cycle is always fine, but if you have any doubts, you can go for screening to check the levels of testosterone and other hormones. Your physician should be able to use these figures to tell you how long your body will take to recover before you can start another cycle.
Testolone is a relatively new chemical with limited data on human trials, and hence there is no one published dosage. Based on some lab research and anecdotal evidence, scientists recommend a dose of between 20 to 30 mg per day taken for a period of between 8 to 12 weeks.
New users are asked to keep the starting doses as low as possible to keep the risk of adverse reactions low. If you are a beginner, you can start with 10 mg per day and stick to that dose for a couple of weeks before you start to increase it gradually.
While RAD-140 is safe for women, it is essential that they keep the dose very low to minimize adverse reactions. Ideally, a woman should be using 5 mg per day for 12 weeks. Some have reported taking up to 10 mg. Experienced female bodybuilders should not experience any issues at such a high dose, but you should never attempt to take more than 10 mg per day. The risks are just too high at that point.
Testolone has a half-life of 20 hours. Taking the substance once should be fine. You can also decide to split the dose into two say 10mg in the morning and 10mg in the evening. This should maintain high levels of RAD-140 in your system throughout the day.
Is it Legal?
Technically, there is no law banning the use of Testolone for personal reasons. At least not yet. However, the compound is supposed to be used for research purposes only. Bodybuilders are still using RAD-140 even though there isn’t enough clinical data to show that it is safe for human consumption.
In 2018, a bill was proposed seeking to ban the use of SARMs. The SARMs Control Act of 2018 was to prohibit the importation and use of all selective androgen receptor modulators including Testolone. The bill had already received significant backing from the leaders of the diet supplement industry. Its, therefore, possible that the rules regulating the distribution of Testolone and the other SARMs could change in the near future.
Other countries in different parts of the world have already banned the use of SARMs. It’s essential that you check on the laws within your specific state/country and see how SARMs are controlled.
The one place where the use of SARMs is never tolerated is in professional sports. Testolone is a performance-enhancing drug that gives athletes an unfair advantage over its competitors, and that’s why the World Anti-Doping Agency prohibits the use of selective androgen receptor modulators. All professional athletes must stay away from this substance.
Bodybuilding Uses of RAD-140
Most bodybuilders rely on a calorie deficit diet to shred the extra fat standing between them and the ultimate chiseled physique. Although it is an effective approach, reducing the amount of calories you are consuming will also have an impact on your muscles. Your body will start to break down muscle cells to produce energy, and this will reduce your lean muscle mass over some time.
Is it possible to avoid that? Yes, it is. How? By including Testolone in your cutting cycle, you will give your lean muscle mass the necessary protection to withstand the ramifications of reduced calorie levels in the body.
In a cutting cycle, you can stack 10 mg per day of Testolone with 20 mg per day of Cardarine (GW501516).
It’s also possible to stack Testolone with Steroids in a cutting cycle. You can use 10 mg/day of RAD-140 and 500 mg/week of Primobolan.
RAD-140 stimulates the growth of lean muscle mass at a faster rate. This makes the SARM a valuable addition in a bulking cycle.
To get the best bulking results, you will need to do more than just taking the SARM. Make sure that your bulking regimen incorporates a high protein diet and vigorous training. You can combine different kinds of workouts to ensure that there is constant stimulation of the muscle tissues. The various exercises should also help in growing the muscle from different angles for a more wholesome outcome.
Testolone can be stacked with different SARMs to deliver amazing bulking results. For instance, you can take 10 mg per day of RAD-140 with LGD-4033 (Ligandrol) 10 mg/day for eight weeks. This stack doesn’t just produce insane gains, but it also increases strength levels significantly.
Another popular RAD-140 stack uses both S23 and MK-677. Take 10mg of RAD-140, 10mg of S23 and 20mg of MK-677 per day for 8 weeks. Both S23 and RAD-140 will boost the growth of muscle tissue substantially. Since MK-677 also increases the levels of growth hormone, you can expect even bigger muscle tissue in record time. In addition to the muscle gains, an increase in growth hormone will also deliver other benefits such as stronger bones and healthier skin and hair. This stack is not meant for everyone though. It is very powerful, and hence only the experienced bodybuilders should use it.
It’s also possible to use Testolone as your testosterone base and stack it with steroids. This will deliver excellent bulking results with reduced adverse reactions. An example of this stack includes 10 mg/day of RAD-140 and 400 mg/week of Deca Durabolin.
Take note that such a stack won’t be as safe as using Testolone alone or with other SARMs.
RAD-140 is one of the youngest SARM in the market which means that it is not the most studied SARM you can get. Therefore, you need to be careful when using the compound since we don’t know much about its long-term effects.
If you are going to give Testolone a shot, I will urge you to be careful with the doses you are taking and the length of your cycles. Men should avoid taking more than 20mg per day. Beginners can start with just 5-10 mg per day. On the other hand, women should stick to 5-10mg per day. Ladies can even begin with doses as low as 2.5mg per day.